González C, Franco M, Londoño A, Valenzuela F
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Breaking paradigms in the treatment of psoriasis: Use of Botulinum toxin for the treatment of plaque psoriasis.

Dermatol Ther. 2020 Sep 19;:

Authors: González C, Franco M, Londoño A, Valenzuela F

Abstract
Some studies have demonstated that neurotransmitters are involved in the pathogenesis of numerous skin conditions, including psoriasis, addressing the close correlation between the skin and the central nervous system. There are reports showing psoriasis improvement after peripheral nervous system injury. In addition, botulinum toxin has been reported as a treatment for several diseases, including psoriasis. This is a proof-of-concept study of botulinum toxin and psoriasis, involving 8 patients with stable and recalcitrant plaques of psoriasis vulgaris. The lesions were 5 cm2 at the maximum. Botulinum toxin Dysport (Ipsen Biopharm, Wrexham, UK), 5 units per cm2 , was administered in one subcutaneous application. Patients were then evaluated 2 and 4 weeks after treatment. Our results indicated a substantial improvement in all patients, 4 weeks after treatment, with no significant side effects. Our preliminary conclusion is that botulinum toxin represents a novel mechanism for interfering with the immunopathogenesis of psoriasis and improving the quality of life of our patients. This article is protected by copyright. All rights reserved.

PMID: 32949180 [PubMed - as supplied by publisher]