Advancing Knowledge. Enhancing Care.
Advancing Knowledge. Enhancing Care.

this weeks' manuscripts on covid-19 & psoriasis

Related Articles

Hydroxychloroquine effects on psoriasis: a systematic review and a cautionary note for COVID-19 treatment.

J Am Acad Dermatol. 2020 May 19;:

Authors: Sachdeva M, Mufti A, Maliyar K, Lytvyn Y, Yeung J

Abstract
BACKGROUND: While evidence suggests that hydroxychloroquine (HCQ) may decrease the viral load in patients with a COVID-19 infection, a number of case reports indicate adverse dermatologic effects of this potential treatment.
OBJECTIVE: To conduct a systematic review of previously reported cases of psoriasis onset, exacerbation, or relapse after HCQ treatment.
METHODS: A comprehensive EMBASE and MEDLINE search of original studies examining adverse effects of HCQ treatment related to psoriasis was conducted. Participant demographics, and details of HCQ administration and psoriasis diagnosis were extracted from 15 articles representing 18 patients.
RESULTS: Females accounted for a significantly larger number of psoriatic cases compared to males and unreported sex (n=14, 77.8% vs. n=2, 11.1% vs n=2, 11.1% respectively). Additionally, 50% (n=9) of the cases did not have a history of psoriasis prior to taking HCQ. Of the 18 patients, 50.0% (n=9) experienced de novo psoriasis, 27.8% (n=5) experienced exacerbation of psoriatic symptoms and 22.2% (n=4) had a relapse of psoriasis after HCQ administration.
CONCLUSIONS: HCQ treatment may result in induction, exacerbation, or relapse of psoriasis. Monitoring for adverse effects of HCQ treatment is necessary, and clinical trials are essential in characterizing the safety profile of HCQ use in patients with a COVID-19 infection.

PMID: 32442699 [PubMed - as supplied by publisher]

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Other relevant manuscripts
IPC's Chief Medical Officer has selected the following manuscripts as important to the understanding of the impact of COVID-19 and psoriasis. 

selections for week of may 18, 2020 

The risk of respiratory tract infections and symptoms in psoriasis patients treated with IL-17-pathway inhibiting biologics: A metaestimate of pivotal trials relevant to decision-making during the COVID-19 pandemic.  Wan MT, Shin DB, Winthrop KL, Gelfand JM. Journal of the American Academy of Dermatology. 2020. doi: https://doi.org/10.1016/j.jaad.2020.05.035.

Practice guidelines for teledermatology in Australia. Abbott LM, Miller R, Janda M, Bennett H, Taylor M, Arnold C, Shumack S, Soyer HP, Caffery LJ. Australas. J Dermatol. 2020 May 3. doi: 10.1111/ajd.13301. [Epub ahead of print]


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